You can get pretty far by defining custom variants of packages and using "package-input-rewriting"[0]. There is also work underway to support "parameterized" p

You can get pretty far by defining custom variants of packages and using "package-input-rewriting"[0]. There is also work underway to support "parameterized" packages akin to USE flags. [0]: https://guix.gnu.org/manual/devel/en/guix.html#index-package_002dinput_002drewriting https://guix.gnu.org/manual/devel/en/guix.html#index-package... It is fairly easy to run a "forked" Guix channel if you want customization on a lower level (say, using '-march=native' everywhere), but I suppose that's a far cry from just editing /etc/make.conf.