Not necessarily. They will likely try to key on something very specific, as this reduces the risk of it triggering on you (creating an autoimmune disorder). So

Not necessarily. They will likely try to key on something very specific, as this reduces the risk of it triggering on you (creating an autoimmune disorder). So natural infection may be less effective. We assume that mutations to the virus that hide it from the natural defenses against a random part, but have no impact on the virility, are generally more frequent and numerous than mutations to the important spike protein.