Falcon 9 has lost 2 payloads over ~120 flights. One was lost on the pad prior to dress rehearsal, so doesn't really count. There were 135 shuttle flights, with

Falcon 9 has lost 2 payloads over ~120 flights. One was lost on the pad prior to dress rehearsal, so doesn't really count. There were 135 shuttle flights, with 2 crews lost (1 on the way up). I would much prefer the odds of flying on Falcon 9, especially since it actually has a viable launch escape system.