2 ms·

Evidence? Specifically? OK I will try. A list of the variants and their DNA code? Or whatever makes them vary. A solid explanation of how these variants are m

Evidence? Specifically? OK I will try. A list of the variants and their DNA code? Or whatever makes them vary. A solid explanation of how these variants are more infectious, not just saying that "The numbers show it" but instead what is the real world physical change in the shape or attack vector that makes them more dangerous, or admiting it is unknown but being studied. True numbers of deaths caused by covid and vaccines, you can't have it both ways and say "They tested positive for the virus and died so it was covid" then at the same time say "yes they got the vaccine but people die all the time, it wasn't nessisarly the vaccine." A genuine record of which vaccines the well to do have recieved. Eg: Celebrities, Politicians, Billionaires. I suspect there are a lot more Pfizer going in their arms but they are telling the rest of us to take what we can get. Maybe drop the racist, sexist, political anti white, anti male, anti Trump bullshit for a while in the media, because fighting the pandemic is just so much more critical right now. Instead of being opportunistic assholes and pushing those adgendas while everyone is scared, locked down and having their loved ones die alone? IDK there is more, like the stuff comming out about Faucci signing off on funding banned research in Wuhan or the 2015 chinese report on weaponizing coronavirii but I think the first couple items on my list would go a long way. And before I catch a bunch more hate Ill leave it there.

mxcrossb 5y ago
For the list of mutations, there is a convenient Wikipedia article [1]. For example, the South Africa variant has mutation E484K which means mutate amino acid 484 from Glutamic Acid to Lysine. It’s just that simple; you could even download a spike protein crystal structure from RCSB and try rolling your own mutations! Why a mutation improves transmission takes a lot of investigating to understand. I am not sure why you were under the impression that we know the mechanisms. If you type something like “E484K molecular dynamics” you can find a lot of computer simulations trying to investigate the mechanism, this is standard biological research. Of course we E484K you have a mutation from a negative to a positive residue, so that might give you a hint why it’s harder for the antibody to stick. I can assure you that here in Japan we do not care about Trump. Perhaps we should be more grateful to his good support for the Pfizer vaccine, which is the one we are now deploying at scale (after the government here did their own review of the evidence). [1] https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2 https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2

mxcrossb 5y ago

For the list of mutations, there is a convenient Wikipedia article [1]. For example, the South Africa variant has mutation E484K which means mutate amino acid 484 from Glutamic Acid to Lysine. It’s just that simple; you could even download a spike protein crystal structure from RCSB and try rolling your own mutations! Why a mutation improves transmission takes a lot of investigating to understand. I am not sure why you were under the impression that we know the mechanisms. If you type something like “E484K molecular dynamics” you can find a lot of computer simulations trying to investigate the mechanism, this is standard biological research. Of course we E484K you have a mutation from a negative to a positive residue, so that might give you a hint why it’s harder for the antibody to stick. I can assure you that here in Japan we do not care about Trump. Perhaps we should be more grateful to his good support for the Pfizer vaccine, which is the one we are now deploying at scale (after the government here did their own review of the evidence). [1] https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2 https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2