3 ms·

Combining a few recent HN topics. I bet you could reverse engineer a prion to develop the mRNA to create it. Pack that gene into something like SARS-CoV-2 tha

by jcims 6y ago

Combining a few recent HN topics. I bet you could reverse engineer a prion to develop the mRNA to create it. Pack that gene into something like SARS-CoV-2 that's highly transmissible but maybe not quite as loud in the body. Let it burp prions into your system while it's humming away then in a year or two a couple billion people die of spongebrain.

blacksmith_tb 6y ago
I would take that bet, prions are proteins, they don't code for anything, they cause normally-shaped versions of the same protein to re-fold when they come into contact with them.
- jcims 6y ago
  Sure but they are still made of amino acids and presumably could be translated from some sequence of mRNA. You might need to modify it slightly to provoke the alternate folding while still maintaining the essential infectious/auto-catalyzing structure.
  - sterlind 6y ago
    ...and that's why I've been terrified of bioterrorism. your plan is simple and elegant and horrifying. making such viruses is getting easier every day. eventually it will be easy enough that some crank will do something like this. Jesus.. we should increase funding for developing pathogen sensors, and put them in public transportation hubs. eventually we'll probably start requiring saliva or nasal swabs from randomly-selected travelers. it sucks but I don't see a better way..
    - jcims 6y ago
      For anyone that isn’t aware: https://www.genscript.com/crispr-services.html https://www.genscript.com/crispr-services.html Gene-mods-R-Us! lol Especially now that we can actually image individual proteins to help discover their structure: https://www.pnas.org/content/114/7/1474 https://www.pnas.org/content/114/7/1474 I’m sure there are complications that make this much more difficult than it seems on the surface, but we should probably get that Mars thing going just in case haha.
      - OnlyANeurosci 6y ago
        Yeah, genetic constructs often don't work well even when you plan for them to work and are doing something "easy". It's not uncommon to have to try 10-30+ variations of adding a His-Tag to a protein (for purifying a protein product like say, insulin). There isn't a ton known about how prions are formed initially, which would be critical to designing one.

by jcims 6y ago

blacksmith_tb 6y ago

I would take that bet, prions are proteins, they don't code for anything, they cause normally-shaped versions of the same protein to re-fold when they come into contact with them.

jcims 6y ago
Sure but they are still made of amino acids and presumably could be translated from some sequence of mRNA. You might need to modify it slightly to provoke the alternate folding while still maintaining the essential infectious/auto-catalyzing structure.
- sterlind 6y ago
  ...and that's why I've been terrified of bioterrorism. your plan is simple and elegant and horrifying. making such viruses is getting easier every day. eventually it will be easy enough that some crank will do something like this. Jesus.. we should increase funding for developing pathogen sensors, and put them in public transportation hubs. eventually we'll probably start requiring saliva or nasal swabs from randomly-selected travelers. it sucks but I don't see a better way..
  - jcims 6y ago
    For anyone that isn’t aware: https://www.genscript.com/crispr-services.html https://www.genscript.com/crispr-services.html Gene-mods-R-Us! lol Especially now that we can actually image individual proteins to help discover their structure: https://www.pnas.org/content/114/7/1474 https://www.pnas.org/content/114/7/1474 I’m sure there are complications that make this much more difficult than it seems on the surface, but we should probably get that Mars thing going just in case haha.
    - OnlyANeurosci 6y ago
      Yeah, genetic constructs often don't work well even when you plan for them to work and are doing something "easy". It's not uncommon to have to try 10-30+ variations of adding a His-Tag to a protein (for purifying a protein product like say, insulin). There isn't a ton known about how prions are formed initially, which would be critical to designing one.