3 ms·

I wonder if this is because it lowers the production of H2O2...? https://www.uniprot.org/uniprot/P27338 https://www.uniprot.org/uniprot/P27338 So maybe supple

by podgaj 5y ago

I wonder if this is because it lowers the production of H2O2...? https://www.uniprot.org/uniprot/P27338 https://www.uniprot.org/uniprot/P27338 So maybe supplements that promote glutathione production would be a better avenue.

The_rationalist 5y ago
Selegiline/BPAP decrease ageing by multiple mechanisms: 1) at non-low doses it increase dopamine level/synthesis, dopamine reduce with aging (15% less at 40, 45% less at 70) and this accelerate ageing (can be said of many things, and it also a strong reason for testosterone replacement therapy) 2) it is a potent antioxydant and is pro apoptotic at the mytochondrial level. This massively reduce accumulation of ROS and is shown to be highly beneficial in many conditions (such as myopathies, and neurodegenerations) 3) there is a third mechanism (effective at low dose) That is apparently more important than the 2 first mechanisms (at least in rats) and show extreme results such as X2 lifespan in rats and X3-4 learning ability https://www.sciencedirect.com/science/article/pii/S0024320516306257?via%3Dihub#f0035 https://www.sciencedirect.com/science/article/pii/S002432051...
- podgaj 5y ago
  1) Correlation is not causation. It could be that the dope mean just coincides with the reduce levels of Hydrogen peroxide. 2) But I explained how it’s an antioxidant , it doesn’t have any antioxidant properties on its own, it just prevents the creation of hydrogen peroxide. 3) It really isn’t much to deduce from the third study.
  - The_rationalist 5y ago
    1) Correlation is not causation. It could be that the dope mean just coincides with the reduce levels of Hydrogen peroxide. MAO-B degrade dopamine it is clearly causative.
    - podgaj 5y ago
      But you’re saying is the dopamine, I’m saying is the hydrogen peroxide that is not produced when the dopamine is not metabolize. Dopamine has no real function in the body other than neurological. But oxidative stress is critically important especially to lifespan.
      - sprucely 5y ago
        A little late to this conversation, but I want to point out that it appears dopamine does have functions other than neurological.[1] Of course one might take the view that immune function is regulated by the nervous system and thus it may not be a direct pathway. [1] https://www.hindawi.com/journals/jir/2016/3160486/ https://www.hindawi.com/journals/jir/2016/3160486/

by podgaj 5y ago

The_rationalist 5y ago

Selegiline/BPAP decrease ageing by multiple mechanisms: 1) at non-low doses it increase dopamine level/synthesis, dopamine reduce with aging (15% less at 40, 45% less at 70) and this accelerate ageing (can be said of many things, and it also a strong reason for testosterone replacement therapy) 2) it is a potent antioxydant and is pro apoptotic at the mytochondrial level. This massively reduce accumulation of ROS and is shown to be highly beneficial in many conditions (such as myopathies, and neurodegenerations) 3) there is a third mechanism (effective at low dose) That is apparently more important than the 2 first mechanisms (at least in rats) and show extreme results such as X2 lifespan in rats and X3-4 learning ability https://www.sciencedirect.com/science/article/pii/S0024320516306257?via%3Dihub#f0035 https://www.sciencedirect.com/science/article/pii/S002432051...

podgaj 5y ago
1) Correlation is not causation. It could be that the dope mean just coincides with the reduce levels of Hydrogen peroxide. 2) But I explained how it’s an antioxidant , it doesn’t have any antioxidant properties on its own, it just prevents the creation of hydrogen peroxide. 3) It really isn’t much to deduce from the third study.
- The_rationalist 5y ago
  1) Correlation is not causation. It could be that the dope mean just coincides with the reduce levels of Hydrogen peroxide. MAO-B degrade dopamine it is clearly causative.
  - podgaj 5y ago
    But you’re saying is the dopamine, I’m saying is the hydrogen peroxide that is not produced when the dopamine is not metabolize. Dopamine has no real function in the body other than neurological. But oxidative stress is critically important especially to lifespan.
    - sprucely 5y ago
      A little late to this conversation, but I want to point out that it appears dopamine does have functions other than neurological.[1] Of course one might take the view that immune function is regulated by the nervous system and thus it may not be a direct pathway. [1] https://www.hindawi.com/journals/jir/2016/3160486/ https://www.hindawi.com/journals/jir/2016/3160486/