5 ms·

Anecdote: Started supplementing with NMN and NAD+ after coming across David Sinclair’s research and book. I injured my knee in a motorcycle high side, and see

Anecdote: Started supplementing with NMN and NAD+ after coming across David Sinclair’s research and book. I injured my knee in a motorcycle high side, and seemed to develop chronic osteoarthritis in the joint. For 2 years I had dealt with this chronic pain and weakness that was only mitigated by leg/rehab exercises. However, the dull pain would come back if I stopped. After taking NMN/NAD+ orally (1 pill every few days) I noticed that for the rest of the day inflammation was very much reduced for me - especially in my knee. A few months later now my knee is a lot better and I haven’t been taking the supplements. I like Sinclair’s research a lot, and my anecdote aligns with many of the results anecdotes he has shared. Maybe my knee just healed naturally, but I think there is something here.

passivate 5y ago
What age group are you in?
voisin 5y ago
What brand supplements do you take and what dose? I did a cursory look online and was nervous about not finding any brands that I was familiar with, and I am concerned about quality given lack of regulations in the supplement market.
- maxqin1 5y ago
  > nervous about not finding any brands that I was familiar with Every "amazing" supplement I hear about encounters this problem. It has become laughable just how scammy/scummy some of the packages look. Here's one of the more recent https://www.amazon.com/Thermal-Non-Stimulant-Thermogenic-Burner-Glaxon/dp/B08FCJ59X1 https://www.amazon.com/Thermal-Non-Stimulant-Thermogenic-Bur... It's recommended by a seemingly serious and reputable doctor. I'm not buying it though. The problem is that the supplement market has the incentive to maximize short-term marketing since their isn't any defensibility without a "proprietary" formula, which is a red flag in itself.
  - rubicon33 5y ago
    You didn’t even answer the op question… is it too much to ask what brand / supplement you took, and how much?
    - deleted 5y ago
      [deleted]
    - usmannk 5y ago
      not the same person
      - rubicon33 5y ago
        I am dumb, and deserve these downvotes.
        stanislavb 5y ago
        You are not dumb, you were just too interested in the answer... ;)
- dillondoyle 5y ago
  I've taken NOW brand for other things like Vitamin D and they seem pretty legitimate. Though the reviews here seem like the side effects are horrible & counter the the purpose. https://www.amazon.com/NOW-Supplements-Nicotinamide-Dinucleotide-D-Ribose/dp/B0030GXSVE/ https://www.amazon.com/NOW-Supplements-Nicotinamide-Dinucleo...
inglor_cz 5y ago
Another anecdote. 42 y.o. male. My eyesight has improved since I started experimenting with NMN; over 1 dioptrie in one eye, actually. The effect was very quick, in a week or so. I definitely did not expect it. Also, my left thumb joint cracks less.
- dmichulke 5y ago
  My irony detector doesn't give me a clear signal on this
  - getlawgdon 5y ago
    Maybe because it's actually your sarcasm detector that's broken...
stanislavb 5y ago
Out of curiosity, if you think it worked, why did you stop taking it? Also, how old are you (in decades) :)?

passivate 5y ago

What age group are you in?

voisin 5y ago

What brand supplements do you take and what dose? I did a cursory look online and was nervous about not finding any brands that I was familiar with, and I am concerned about quality given lack of regulations in the supplement market.

maxqin1 5y ago
> nervous about not finding any brands that I was familiar with Every "amazing" supplement I hear about encounters this problem. It has become laughable just how scammy/scummy some of the packages look. Here's one of the more recent https://www.amazon.com/Thermal-Non-Stimulant-Thermogenic-Burner-Glaxon/dp/B08FCJ59X1 https://www.amazon.com/Thermal-Non-Stimulant-Thermogenic-Bur... It's recommended by a seemingly serious and reputable doctor. I'm not buying it though. The problem is that the supplement market has the incentive to maximize short-term marketing since their isn't any defensibility without a "proprietary" formula, which is a red flag in itself.
- rubicon33 5y ago
  You didn’t even answer the op question… is it too much to ask what brand / supplement you took, and how much?
  - deleted 5y ago
    [deleted]
  - usmannk 5y ago
    not the same person
    - rubicon33 5y ago
      I am dumb, and deserve these downvotes.
      - stanislavb 5y ago
        You are not dumb, you were just too interested in the answer... ;)
dillondoyle 5y ago
I've taken NOW brand for other things like Vitamin D and they seem pretty legitimate. Though the reviews here seem like the side effects are horrible & counter the the purpose. https://www.amazon.com/NOW-Supplements-Nicotinamide-Dinucleotide-D-Ribose/dp/B0030GXSVE/ https://www.amazon.com/NOW-Supplements-Nicotinamide-Dinucleo...

inglor_cz 5y ago

Another anecdote. 42 y.o. male. My eyesight has improved since I started experimenting with NMN; over 1 dioptrie in one eye, actually. The effect was very quick, in a week or so. I definitely did not expect it. Also, my left thumb joint cracks less.

dmichulke 5y ago
My irony detector doesn't give me a clear signal on this
- getlawgdon 5y ago
  Maybe because it's actually your sarcasm detector that's broken...

stanislavb 5y ago

Out of curiosity, if you think it worked, why did you stop taking it? Also, how old are you (in decades) :)?