We have come a long way since 2006 in terms of both storage and RAM. There are a lot of Varnish servers out there running straight out of RAM, and some of the

We have come a long way since 2006 in terms of both storage and RAM. There are a lot of Varnish servers out there running straight out of RAM, and some of them have a /lot/ of RAM. But the most important question is your data set and your traffic pattern, and whatever that is, Varnish can deal with it, given suitable hardware.