Itanium can be configured to run in either endianness (it's "bi-endian"). Windows on Itanium always ran in little-endian mode and did not support big-endian mod

Itanium can be configured to run in either endianness (it's "bi-endian"). Windows on Itanium always ran in little-endian mode and did not support big-endian mode. The same was true of PowerPC. Windows never ran in big-endian mode on any architecture.