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> CJD test came back negative So a CJD test is usually staining a biopsy with congo red and observing apple-green birefringence in the image. This generally w
by dnautics 6y ago
> CJD test came back negative
So a CJD test is usually staining a biopsy with congo red and observing apple-green birefringence in the image. This generally works to detect amyloid plaques, which is common to all prions. So unless there was a lab mistake, the prion is localized elsewhere from where the biopsies are being done (FFI, for example, localizes to a different part of the brain) or they were using some other procedure, it's seems pretty unlikely this is a prion disease.
- omgwtfbbq 6y agoAre there other tests to determine prion disease related brain degeneration? Seems hard to believe they can't identify at all what the cause is.
- eganp 6y agoIntracranial inoculation of infected tissue is the old-school way to assay for prion activity. Sometimes it takes a few years to get an answer though, especially in cross-species assays [0]. [0] https://link.springer.com/chapter/10.1007/978-1-4614-5338-3_9 https://link.springer.com/chapter/10.1007/978-1-4614-5338-3_...