Could mRNA injection temporary restore activity for loss-of-function mutations like p53 deletion in cancer? The general, inherent hurdle in cancer treatment is

Could mRNA injection temporary restore activity for loss-of-function mutations like p53 deletion in cancer? The general, inherent hurdle in cancer treatment is discriminating individualist, misbehaving cells from cooperative, healthy ones. From what I got, p53 isn't not expressed in healthy cells, but rather inactivated. Therefore it may be possible to systemically restore it in all cells, without inducing apoptosis in well-behaving cells. This would be exciting, because it would enable cancer treatment avoiding selection based on cell signature, or "finding a target". Effectively restoring functionality of cell cycle guardians, which will then suicide the cancer cells seems like an attack vector very hard to evade for cancer cells. You wouldn't ask "who is misbehaving?", but rather shortly reign "everybody does as I say, now!". Cancer cells can get rid of all the surface proteins (targeted by immunotherapy) and even gain root acce.. omnipotent stem cell characteristics (game over), they cannot shake the programmatic hallmarks of cancer, without stop being cancer. And the most important feature isn't rabid metabolism (targeted by chemo), but unchecked cell division. Chemo doesn't work well on indolent/non-aggressive cancers, as their metabolic signature is not discriminating. But who cares, if cells lost e.g. the p53 altogether, if we can force the machinery onto them regardless? No need to diff/patch the source, bring the bytecode to the compiler and fix the system until broken for good. All we want is them to "wake up" briefly and take responsibility for the mess they got at hand. (Of course, it wouldn't be possible to flood the body with "activated p53", as that would probably suicide all cells (although it makes for a pretty scifi murder-agent), and the activation itself may offer an escape... until people figure out the whole shop.) * https://en.wikipedia.org/wiki/P53 https://en.wikipedia.org/wiki/P53 * https://en.wikipedia.org/wiki/The_Hallmarks_of_Cancer https://en.wikipedia.org/wiki/The_Hallmarks_of_Cancer