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Thank you, I failed to find this one in my previous literature search. I don't have it handy now, but for at least one SARS-Cov-1 vaccine candidate everything

Thank you, I failed to find this one in my previous literature search. I don't have it handy now, but for at least one SARS-Cov-1 vaccine candidate everything seemed fine, and good immediate antibody response (as in this paper), but another challenge 3 months later had an ADE response with worse outcomes than a naive infection. IIRC it was done in felines, not in primates.

exPerTrust 5y ago
Beagle don't let yourself convince so easily, you are still right, they didn't done long term studies in animals, thus its not wrong to say that they skipped long term efficacy or safety in animals. Meaning they skipped it. In who is being done the long term studies? Yes, that's what you thinking.. in humans. These should be done in animals first for years, but what have they done? They skipped it... If you read carefully the study lasted 8 weeks and 15 days only. Quote "At week 8 (4 weeks after the second vaccination), all animals were challenged with the wild virus)", then "lung sections from animals that were killed at day 14 or 15". So, only two months and 15 days max, then when the vaccine was authorized they jumped directly to humans. While in this animal trial they only waited 4 weeks after the second vaccination and challenged, the challenge you mention that was done only 3 months later, this is a small example of a mini long term follow up. They havent done that at all.. They skipped it, just to do the follow up in.. humans, so yes humans are still being trialed with the vaccines. When the next wave comes in the winter, more than 3 months from today, 7 months ahead, in October, it will be a catastrophe caused by ADE.