4 ms·

Interesting. Is there a significant difference in total number of viral particles versus vaccine particles your cells are exposed to, over the course of the inf

Interesting. Is there a significant difference in total number of viral particles versus vaccine particles your cells are exposed to, over the course of the infection/vaccination?

rolph 5y ago
in general terms yes, there is no real hard number on minimal number of viral particles required to result in infection, its most likely a small number compared to the number of vaccine particles in a dosage. assuming 30 micrograms dosage in a volume of 300 microliters that is a very large number of particles in one place. this is not a lot of vaccine, but this [30micrograms] would be quite a lot of viral particles. something to keep in mind is the fuzz of biological systems. molecular processes can have more than one outcome but there is a general bias toward an overall stability, so when a vaccine is produced, there is a certain amount of fuzz to it in the form of particles that dont assemble correctly or ar otherwise non desireable, processing the vaccine keeps these characters to a minimum. the same thing happens to the virus, the fuzz portion being in someway unable to replicate or enter a cell, just out of the way the fuzzy dice roll. so its hard to pin down a number of minimally effective dose for either case, however virus amplifies past the original dose, and spreads to mutiple locations, signaling any molecular system that can be bound to, in this case vast preference being given to ACE-2, resulting in perturbation of the RAS system and the now stereotypic covid symptoms so viral particles amplify over time, and over a spatial distribution, vaccine particles stay in site and dont replicate and dont migrate to interact with other cells in the tissue or throughout the body.
- darkerside 5y ago
  Should we expect localized endothelial inflammation in that case?
  - rolph 5y ago
    no you shouldnt, the vaccine is going into muscle tissue, the muscle will experience inflammation due to the presence of the vaccine, this means things are working as planned, and the tissue is opening up to allow the immune system access to the site. you wont find endothelium in the muscle tissue, and you wont get a systemic distribution of vaccine or free floating spike protien.

Interesting. Is there a significant difference in total number of viral particles versus vaccine particles your cells are exposed to, over the course of the infection/vaccination?

rolph 5y ago

in general terms yes, there is no real hard number on minimal number of viral particles required to result in infection, its most likely a small number compared to the number of vaccine particles in a dosage. assuming 30 micrograms dosage in a volume of 300 microliters that is a very large number of particles in one place. this is not a lot of vaccine, but this [30micrograms] would be quite a lot of viral particles. something to keep in mind is the fuzz of biological systems. molecular processes can have more than one outcome but there is a general bias toward an overall stability, so when a vaccine is produced, there is a certain amount of fuzz to it in the form of particles that dont assemble correctly or ar otherwise non desireable, processing the vaccine keeps these characters to a minimum. the same thing happens to the virus, the fuzz portion being in someway unable to replicate or enter a cell, just out of the way the fuzzy dice roll. so its hard to pin down a number of minimally effective dose for either case, however virus amplifies past the original dose, and spreads to mutiple locations, signaling any molecular system that can be bound to, in this case vast preference being given to ACE-2, resulting in perturbation of the RAS system and the now stereotypic covid symptoms so viral particles amplify over time, and over a spatial distribution, vaccine particles stay in site and dont replicate and dont migrate to interact with other cells in the tissue or throughout the body.

darkerside 5y ago
Should we expect localized endothelial inflammation in that case?
- rolph 5y ago
  no you shouldnt, the vaccine is going into muscle tissue, the muscle will experience inflammation due to the presence of the vaccine, this means things are working as planned, and the tissue is opening up to allow the immune system access to the site. you wont find endothelium in the muscle tissue, and you wont get a systemic distribution of vaccine or free floating spike protien.