3 ms·
Yeah we've known this for over 10 years, zero surprise here. There were literally popular books written saying that this would be the mechanism of action for no
by Alex3917 5y ago
Yeah we've known this for over 10 years, zero surprise here. There were literally popular books written saying that this would be the mechanism of action for novel coronavirus pandemics (and how to treat them) years before the current pandemic even started, e.g.:
https://www.amazon.com/Herbal-Antivirals-Remedies-Resistant-Infections/dp/1612121608 https://www.amazon.com/Herbal-Antivirals-Remedies-Resistant-...
Here is the direct quote from the book, published in 2013:
"Once receptors on these cells are compromised there is enhanced vascular permeability, increased lung edema, neutrophil accumulation, and worsened lung function. In essence, once the virus begins attaching to ACE-2, ACE-2 function begins to be destroyed. ACE-2 function also tends to be less dynamic as people grow older, hence the more negative the effects of SARS infection on the elderly. [...] ACE (in contrast with ACE-2) inhibitors increase the presence of ACE-2 and help protect the lungs from injury."
- dctoedt 5y agoNot my field (I can spell DNA) but this recent piece seemed of interest. FTA: "A large meta-analysis provides yet more evidence that ACE inhibitors and angiotensin receptor blockers (ARBs) pose no harm to patients with COVID-19 and may even be associated with protective benefits, particularly in patients with hypertension." https://www.tctmd.com/news/continue-ace-inhibitorsarbs-covid-19-new-study-confirms https://www.tctmd.com/news/continue-ace-inhibitorsarbs-covid...
- Alex3917 5y agoAlso women and smokers are underrepresented among hospitalized patients, which was the first confirmatory evidence from over a year ago.
- piva00 5y agoI know nothing about physiology (apart from up to high school level, so... Nothing), could you expand on how smokers and women relate to ACE-2?
- sudosysgen 5y agoNicotine upregulates ACE2 expression, but I don't know about women.
- Blackthorn 5y agoYes, that's why they went looking to verify that hypothesis and lay out the mechanism that the virus acts...
- justicezyx 5y agoIs this Amazon book on herbal effects real? I am pretty familiar with Chinese traditional medicine, but their effectiveness is very dubious. The author does not look like a medical professional either.
- jpxw 5y agoIt’s unscientific nonsense, don’t waste your time.
- darkhorn 5y agoSo, some people were studying new kinds of viruses? Oh, okay, yeah, here https://www.wired.com/2013/05/h5n1-h1n1-reassortment/ https://www.wired.com/2013/05/h5n1-h1n1-reassortment/