I would disagree that transgenic A-beta mice are a clinically relevant model. I mean, I understand why we started there -- at first glance Alzheimer's is amyloi

I would disagree that transgenic A-beta mice are a clinically relevant model. I mean, I understand why we started there -- at first glance Alzheimer's is amyloidosis in the brain. But after all this time, it's pretty clear that removing amyloid doesn't cure AD, and consequently that overexpressing amyloid in a mouse is not a good animal model of AD.