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> Can flu jabs be made more effective, and multi-strain, using mRNA vaccine technology? That's a genuinely new tool in the toolbox. In theory, yes; in practice
by valarauko 5y ago
> Can flu jabs be made more effective, and multi-strain, using mRNA vaccine technology? That's a genuinely new tool in the toolbox.
In theory, yes; in practice, I don't see this happening for some time (outside of a possible combined SARS-CoV-2 booster + flu combo). The mRNA vaccines are expensive to produce, and it's hard to justify a cost multiplier that's a magnitude higher & harder to produce. Flu vaccines are already multi-strain, and the current techniques already attempt to generate the recombinant strains that might be generated in the wild. Flu mutates faster than the current egg based vaccine production pipeline can handle, and the mRNA vaccine pipeline is orders of magnitude smaller in scale. This will change, of course.
- JulianMorrison 5y agoIf I understand it right, mRNA isn't so much exactly hard, as bespoke. It's a new technology and not many places are fitted out to make it. It can eventually be expected to become much cheaper. And mRNA can keep up with flu. It can also target things in a more deliberate way, if I understand it. So a protein could be selected that is common to many variants and hard for the virus to do without.