3 ms·
It's that transgenic beta-amyloid mice are not humans with Alzheimer's. BUT! As another neuro PhD: this is still an important finding for our understanding of
by tdaltonc 5y ago
It's that transgenic beta-amyloid mice are not humans with Alzheimer's.
BUT!
As another neuro PhD: this is still an important finding for our understanding of protein (dis)aggregation in the brain. The opposite finding was totally possible. The protein disaggregation could have been independent of CSF flow. The typical HN hot-take is "not so fast, this translational research actually underdelivers," but I prefer, "this fundamental neurosci research has the added bonus of being preformed on a clinically relevant model."
- ProjectArcturis 5y agoI would disagree that transgenic A-beta mice are a clinically relevant model. I mean, I understand why we started there -- at first glance Alzheimer's is amyloidosis in the brain. But after all this time, it's pretty clear that removing amyloid doesn't cure AD, and consequently that overexpressing amyloid in a mouse is not a good animal model of AD.