This is addressed in the article: Now, there have been debates over the years about whether you’d get a more effective vaccine that way, with a “replication-co

This is addressed in the article: Now, there have been debates over the years about whether you’d get a more effective vaccine that way, with a “replication-competent” adenovirus, but generally it’s believed that you can do fine with the “replication-incompetent” ones, which let you *not* give your patients a new viral infection at the same time.