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Unlikely, because the part of the adenovirus they delete that allows it to replicate is what they replace with the portion that generates the spike protein anti
by Exmoor 5y ago
Unlikely, because the part of the adenovirus they delete that allows it to replicate is what they replace with the portion that generates the spike protein antigen. So if some of the adenovirus is replicating it's inherently not doing what you want it to do to produce an immune response.
- petertodd 5y agoNot inherently. We don't know how it's replicating. Furthermore, this isn't even an an/or situation: the actual virus in the vial of vaccine isn't going to be 100% uniform. You could have both virus material that can and can't replicate simultaneously. The extra immune response induced by the subset that can replicate might even make the immune response against the spike protein stronger, even if your theory is correct. Remember that vaccines usually have to use adjuvants to induce a stronger immune response than the active part itself does. An actual infection could do that quite effectively.