There's a lot of research showing that yes, it does. Here's a quote: "Long-term, heavy drinking can actually alter the brain’s chemistry, re-setting what is “n

There's a lot of research showing that yes, it does. Here's a quote: "Long-term, heavy drinking can actually alter the brain’s chemistry, re-setting what is “normal.” It causes the release of higher amounts of cortisol and adrenocorticotropic hormone. When this hormonal balance is shifted, it impacts the way the body perceives stress and how it responds to it.21,22 For example, a long-term heavy drinker may experience higher levels of anxiety when faced with a stressful situation than someone who never drank or who drank only moderately" from https://pubs.niaaa.nih.gov/publications/AA85/AA85.htm https://pubs.niaaa.nih.gov/publications/AA85/AA85.htm You can search for alcohol's impact on GABA, cortisol, or just stress in general and find plenty of science showing that there are significant negative impacts to how the body responds to stress or various key hormones due to damage from alcohol.