4 ms·

Incorrect, only certain areas in Brazil and India are using Ivermectin which makes for excellent epidemiological studies showing ivermectin's effectiveness in a

by herenow2021 5y ago

Incorrect, only certain areas in Brazil and India are using Ivermectin which makes for excellent epidemiological studies showing ivermectin's effectiveness in areas that use it versus areas that don't: https://covid19criticalcare.com/ivermectin-in-covid-19/epidemiologic-analyses-on-covid19-and-ivermectin/ https://covid19criticalcare.com/ivermectin-in-covid-19/epide... (India and Brazil are towards, the bottom of the page, several other countries data show identical results where introducing ivermectin treatments causes death rates to drop)

raverbashing 5y ago
> only certain areas in Brazil Incorrect, if you go to any pharmacy in any area of Brazil you'll find it being liberally sold even without a prescription. (one of multiple references https://g1.globo.com/sp/sao-paulo/noticia/2021/03/29/uso-de-medicamentos-do-kit-covid-pode-ter-provocado-a-morte-de-tres-pessoas-em-sp-outro-paciente-fez-transplante-de-figado.ghtml https://g1.globo.com/sp/sao-paulo/noticia/2021/03/29/uso-de-... ) Also go look up the numbers of Drug-induced hepatitis caused by Ivermectin in Brazil
- herenow2021 5y ago
  My understanding is that even if the drug is available in Brazil OTC it has become politicized, so it's not considered standard of care. Do you have any links where health authorities in Brazil have made it standard of care? Ivermectin is incredibly safe. "Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year." https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.20293 https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.20... "Hepatic adverse events Ivermectin was suspected to be a hepatotoxicant. In fact, this claim reproduced in several publications was based on few individual case reports [Sparsa, 2006; Veit et al., 2006; Hirota et al., 2011] where the causal relationship with ivermectin treatment was not convincingly established. The last update of LiverTox [2018], a database of drug-induced hepatotoxicity, did not classify ivermectin as a known hepatotoxicant, a conclusion recently confirmed by the US National Institutes of Health [NIH, 2021]." Taken from a recent 48 page review of the the entire literature on Ivermectin safety by a medical toxicologist: https://www.medincell.com/wp-content/uploads/2021/03/Clinical_Safety_of_Ivermectin-March_2021.pfd https://www.medincell.com/wp-content/uploads/2021/03/Clinica... (edit: not 50,000 liver failures, 56,000 er room visits :)
  - raverbashing 5y ago
    > it's not considered standard of care. Do you have any links where health authorities in Brazil have made it standard of care? "Nobody cares" about standard of care. The medical college (CRM) has pretty much said that the doctors are free to prescribe whatever they want > Ivermectin is incredibly safe. Yes, at the recommended doses for parasite control (which is a single or dual dose), not for usage for several consecutive days or weeks (and I agree with the Paracetamol criticism)
    - amnot_billgates 5y ago
      Anti-depressants are approved after a few weeks of study, and people use them for years without safety concerns. People have taking 10 times the dose of regular ivermectin without harm (https://pubmed.ncbi.nlm.nih.gov/12362927/ https://pubmed.ncbi.nlm.nih.gov/12362927/). I guess we are in slightly uncharted waters with ivermectin, but there is no evidence from the people who chronically prophylax for covid that regular dosing has caused them issues. And ivermectin is safest of the current covid treatments, so I find it hard to accept that we shouldn't use it because of safety concerns (for comparison, since 1992 the pharmocavigilance database shows less than 1 death per year from ivermectin, where Remdesivir has 500+ deaths, vaccines has over 2000 deaths with only months of usage).

raverbashing 5y ago

> only certain areas in Brazil Incorrect, if you go to any pharmacy in any area of Brazil you'll find it being liberally sold even without a prescription. (one of multiple references https://g1.globo.com/sp/sao-paulo/noticia/2021/03/29/uso-de-medicamentos-do-kit-covid-pode-ter-provocado-a-morte-de-tres-pessoas-em-sp-outro-paciente-fez-transplante-de-figado.ghtml https://g1.globo.com/sp/sao-paulo/noticia/2021/03/29/uso-de-... ) Also go look up the numbers of Drug-induced hepatitis caused by Ivermectin in Brazil

herenow2021 5y ago
My understanding is that even if the drug is available in Brazil OTC it has become politicized, so it's not considered standard of care. Do you have any links where health authorities in Brazil have made it standard of care? Ivermectin is incredibly safe. "Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year." https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.20293 https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.20... "Hepatic adverse events Ivermectin was suspected to be a hepatotoxicant. In fact, this claim reproduced in several publications was based on few individual case reports [Sparsa, 2006; Veit et al., 2006; Hirota et al., 2011] where the causal relationship with ivermectin treatment was not convincingly established. The last update of LiverTox [2018], a database of drug-induced hepatotoxicity, did not classify ivermectin as a known hepatotoxicant, a conclusion recently confirmed by the US National Institutes of Health [NIH, 2021]." Taken from a recent 48 page review of the the entire literature on Ivermectin safety by a medical toxicologist: https://www.medincell.com/wp-content/uploads/2021/03/Clinical_Safety_of_Ivermectin-March_2021.pfd https://www.medincell.com/wp-content/uploads/2021/03/Clinica... (edit: not 50,000 liver failures, 56,000 er room visits :)
- raverbashing 5y ago
  > it's not considered standard of care. Do you have any links where health authorities in Brazil have made it standard of care? "Nobody cares" about standard of care. The medical college (CRM) has pretty much said that the doctors are free to prescribe whatever they want > Ivermectin is incredibly safe. Yes, at the recommended doses for parasite control (which is a single or dual dose), not for usage for several consecutive days or weeks (and I agree with the Paracetamol criticism)
  - amnot_billgates 5y ago
    Anti-depressants are approved after a few weeks of study, and people use them for years without safety concerns. People have taking 10 times the dose of regular ivermectin without harm (https://pubmed.ncbi.nlm.nih.gov/12362927/ https://pubmed.ncbi.nlm.nih.gov/12362927/). I guess we are in slightly uncharted waters with ivermectin, but there is no evidence from the people who chronically prophylax for covid that regular dosing has caused them issues. And ivermectin is safest of the current covid treatments, so I find it hard to accept that we shouldn't use it because of safety concerns (for comparison, since 1992 the pharmocavigilance database shows less than 1 death per year from ivermectin, where Remdesivir has 500+ deaths, vaccines has over 2000 deaths with only months of usage).