What's the argument for building in debug mode vs specifying -g to the compiler to build with debug symbols? I've previously encountered bugs that stubbornly r

What's the argument for building in debug mode vs specifying -g to the compiler to build with debug symbols? I've previously encountered bugs that stubbornly refused to reproduce in a non-optimized build. One thing that comes to mind is `#ifdef DEBUG`-style macros, although I'm curious if there's anything else I'm missing. Omitted stack frames, e.g. from inlining, perhaps?