4 ms·
I was under the impression adenovirus based vaccines are worse in the long run because the adenovirus acts as a vehicle for the proteins we're immunizing agains
by GloriousKoji 5y ago
I was under the impression adenovirus based vaccines are worse in the long run because the adenovirus acts as a vehicle for the proteins we're immunizing against (coivd) and that immunity can also occur against the adenovirus rendering it useless as a vehicle for proteins in the future.
- passivate 5y agoYes, there are certain strains that wouldn't work as vectors. HAd26 (used in J&J) has not shown reduced immunogenicity based on studies conducted. It was used in other vaccines previously, and that hasn't impacted its performance here. While it's not a problem now, the situation might change in the future, so you were right to ask the question. These issues of pre-existing immunity are taken seriously inside vaccine companies too. (Note that while I work in biotech, I'm not claiming to be an expert on this topic, so don't take these as definitive claims of truth. People shouldn't be taking HN comments as a source of any kind of medical advice anyway.)
- deleted 5y ago[deleted]