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I got confused as the same thing was reported in Oxford Astrozenica vaccine recipients. I wasn't sure if they're the same vaccine (they're not). So I read up a

I got confused as the same thing was reported in Oxford Astrozenica vaccine recipients. I wasn't sure if they're the same vaccine (they're not). So I read up a bit. The same sort of clots occur in people who have been given heparin (a blood thinner). It's even called "heparin induced" in people using heparin. https://en.wikipedia.org/wiki/Post-vaccination_embolic_and_thrombotic_events https://en.wikipedia.org/wiki/Post-vaccination_embolic_and_t... People on either vaccine have been found to have an immune response to "platelet factor 4" (PF4). PF4s job is to moderate substances like heparin. I wonder if PF4 is similar to spike protein somehow? I wonder how long the immune response lasts? I guess it's not super useful as it wouldn't make sense to give people a blood thickener (a coagulant?) prophylacticly. Maybe we need to consider whether this is appropriate for people on Heparin or similar medications? I'm no doctor so don't take this as discouragment, I'm just musing. I have Oxford AZ (1 dose so far) and it was fine.

jrochkind1 6y ago
Even the experts still don't know what could be causing these side effects, or why it would be similar between the two vaccines. However, when they want to investigate it, what they'll be looking at is that both the Astrozenica and J&J vaccines use adenovirus vaccine technology, and the Moderna and Pfizer do not, so there could be something in common there that leads to the side effects. I think people only have guesses they aren't super confident in as to what that could be at present.
thro1 6y ago
> I wonder if PF4 is similar to spike protein somehow? it may be not only PF4: ..of 2,688 human proteins. In some of his own covid patients he found antibodies targeting 30 other important signaling agents besides interferon, Antibodies which: can somehow be created by covid itself , have the potential to last a lifetime. https://news.ycombinator.com/item?id=26915143 https://news.ycombinator.com/item?id=26915143 I guess that the spike another function could be a trap for the immune system and antibodies - resulting in production of autoantibodies - and that's very wise choice, which parts of that trap/virus are used in vaccines.

jrochkind1 6y ago

Even the experts still don't know what could be causing these side effects, or why it would be similar between the two vaccines. However, when they want to investigate it, what they'll be looking at is that both the Astrozenica and J&J vaccines use adenovirus vaccine technology, and the Moderna and Pfizer do not, so there could be something in common there that leads to the side effects. I think people only have guesses they aren't super confident in as to what that could be at present.

thro1 6y ago

> I wonder if PF4 is similar to spike protein somehow? it may be not only PF4: ..of 2,688 human proteins. In some of his own covid patients he found antibodies targeting 30 other important signaling agents besides interferon, Antibodies which: can somehow be created by covid itself , have the potential to last a lifetime. https://news.ycombinator.com/item?id=26915143 https://news.ycombinator.com/item?id=26915143 I guess that the spike another function could be a trap for the immune system and antibodies - resulting in production of autoantibodies - and that's very wise choice, which parts of that trap/virus are used in vaccines.