Often yes. "Medical devices" covers a large array of products from in-vitro/small implantable to things similar to laboratory equipment (think patient monitorin

Often yes. "Medical devices" covers a large array of products from in-vitro/small implantable to things similar to laboratory equipment (think patient monitoring) or industrial (MRI and the like, autoclaves, etc). "Safety" is not really achieved on a per-component basis, but as a sum of the parts. As for other comments in this thread, depending on your device, it can see a great deal of thermal stress (steam autoclaves) or vibration (MRI), and not all components in autos are experiencing the total vibrations from internal combustion engines. I've typically designed in components with extended temperature ranges, most commonly 85C+ or even 125C. This increases the reliability and extends the life of your product. "Automotive-grade" typically means extra lot testing, and some parameters may vary in the datasheet due to the way the parts were validated by the manufacturer, even though they're technically the same part. For instance, I am using a Texas Instruments part that became nearly impossible to source. I had the automotive version in my bill of materials because at time of the design, it was the only version out. An alternative made by TI looked like a good fit, but a few key parameters in the datasheet didn't quite line up. It was because the automotive was tested at like 13.8V input whereas the newer "industrial" part was tested with 24V and slightly different loads. Same exact component, tested slightly differently.