No, I was explicitly suggesting that neurotoxic amines in coffee may be building up in some, possibly genetically predisposed heavy coffee drinkers, causing los

No, I was explicitly suggesting that neurotoxic amines in coffee may be building up in some, possibly genetically predisposed heavy coffee drinkers, causing loss of dopaminergic neurons and ultimately dementia, or other neurological disorders. This exact mechanism has been shown to be the cause of a very common neurological disorder called essential tremor. Patients have a genetic predisposition for building up tremor-inducing Harmala alkaloids due to reduced metabolism.