3 ms·
Thanks for the links! I made a first pass through them, and will look at them more. I appreciate the extra data. There's a lot of details to mull over, some of
by mikem170 6y ago
Thanks for the links! I made a first pass through them, and will look at them more. I appreciate the extra data. There's a lot of details to mull over, some of it seemingly conflicting.
For example, your linked article [0] mentions "Currently available vaccines will likely offer protection against prevailing variants of SARS-CoV-2", but also says "The risk of immune escape is hard to predict long term"
You linked article [1] says "it takes about eight times as many of the antibodies produced by the Moderna vaccine to neutralize the B.1.351 variant" but also says "so there is enough antibody still to neutralize the virus."
And your linked article [2] says "coronaviruses change more slowly than most other RNA viruses" and "other genome data have emphasized this stability" and "sluggish mutation rate" and "if a mutation did help the virus to spread faster, it probably happened earlier, when the virus first jumped into humans" and "no signs of natural selection for any of the variants" and “probably the virus binds to ACE2 about as well as it needs to right now" and "these strains remain constant, more or less".
At one point in [2] it is mentioned "I wouldn’t be surprised if this virus is maintained as a more common, cold-causing coronavirus". I've heard that mentioned as a likely outcome in other places [3].
The above article wrapped up with "Worrisome mutations could also become more common if antibody therapies aren’t used wisely", "Vaccines arouse less concern on this score because, like the body’s natural immune response, they tend to elicit a range of antibodies."
This reminded me of this doctor [4], who was warning about the dangers of the covid vaccination campaign setting us up for a much worse disaster by pressuring the widely circulating virus to evolve into something much more dangerous. The statement above near the end of article [2] seems to indicate that vaccines are not as likely to
cause this as are antibody therapies.
I'm not sure what you were trying to get at with t-cells. I keep reading things that say t-cells from prior coronaviruses infections confer some protection against covid-19, even from other coronaviruses. Here's another link [5]. Are you saying that is not so?
When it comes to the fear of immunity-evading coronavirus mutations I seem to keep hearing scientists say it is possible, but not likely. I think that is an important distinction to make.
[0] https://www.bmj.com/content/372/bmj.n771#xref-ref-8-1 https://www.bmj.com/content/372/bmj.n771#xref-ref-8-1
[1] https://www.advisory.com/en/daily-briefing/2021/04/16/variants-vaccines https://www.advisory.com/en/daily-briefing/2021/04/16/varian...
[2] https://www.nature.com/articles/d41586-020-02544-6 https://www.nature.com/articles/d41586-020-02544-6
[3] https://www.statnews.com/2020/02/04/two-scenarios-if-new-coronavirus-isnt-contained/ https://www.statnews.com/2020/02/04/two-scenarios-if-new-cor...
[4] https://www.deblauwetijger.com/wp-content/uploads/2021/03/Geert-vanden-Bossche.pdf https://www.deblauwetijger.com/wp-content/uploads/2021/03/Ge...
[5] https://www.sciencemag.org/news/2020/05/t-cells-found-covid-19-patients-bode-well-long-term-immunity https://www.sciencemag.org/news/2020/05/t-cells-found-covid-...