3 ms·
The study you cite isn't really in conflict with the parent study. They note that the number of individuals with Alzheimer's Disease in the study was too small
by dmicah 5y ago
The study you cite isn't really in conflict with the parent study. They note that the number of individuals with Alzheimer's Disease in the study was too small to develop a non-linear model relating sleep duration to AD risk:
Pg. 858:
"Similarly, short and long sleep duration and poor
sleep quality have also been linked with an increased risk
of dementia. Although a similar J-shaped association was
observed in our observational analysis, we were limited to
performing only the linear MR analysis, as the non-linear
MR method requires a large number of cases and
individual-level data. In our linear MR analysis, we found
no clear evidence that an increased sleep duration was associated with a higher risk of all-cause dementia in UK
Biobank or with AD in IGAP. This is unsurprising, as the
true association might be non-linear and we were limited
with only 1343 dementia cases in UK Biobank. Also, IGAP
does not capture non-AD dementia types and comprises an
older and more heterogeneous population."
"Results for risks of dementia and AD are still too imprecise to draw any definitive conclusions. Our findings suggest that, in clinical care, attention should be paid to sleep-duration patterns and improved sleep habits could represent a potential therapeutic target for cognition."
- carbocation 5y agoIt doesn't disprove the parent study, but it certainly is not supportive of some of the causal interpretations of the observational study.