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That's how I understood so appreciate all the above responses in response to mRNA Do Not last long. First I think it is quite incredible to have such a vaccina

That's how I understood so appreciate all the above responses in response to mRNA Do Not last long. First I think it is quite incredible to have such a vaccination out so quickly. As the pandemic eases are we in a situation needing to continue booster shots say on some reoccurring basis as a preventative measure? I am not very clear on the virus itself whether it eventually gets eradicated over time. Or something a bit more reactive where it is possible to get a shot after infected or having symptoms and whether mRNA works in this way as well on a reactive basis.

valarauko 6y ago
> * As the pandemic eases are we in a situation needing to continue booster shots say on some reoccurring basis as a preventative measure?* Most likely. SARS-CoV-2 is now endemic in the human population & unlikely to die out. The general impression in the scientific community is that the current set of vaccines should be protective for at least a year or two, at which point variants will have emerged that evade the vaccines developed on the Wuhan strain. Booster shots developed on these new variants would be required for the foreseeable future. > Or something a bit more reactive where it is possible to get a shot after infected or having symptoms and whether mRNA works in this way as well on a reactive basis. In principle this is possible - some vaccines are capable of arresting an active infection, though that is highly specific to certain pathogens. This is not something current COVID vaccines can do.
Tagbert 6y ago
The mRNA vaccine process has been developed over the last 10 years or so. The actual spike protein was identified early, so the main work was to create the mRAN sequence for that protein. Not easy but the tools have gotten much better in recent years. This was the first large-scale use of this kind of vaccine so it is an amazing field test of the process. Normally that would be a slower, incremental process but the risk from Covid forced them to simplify and speed up the process.

valarauko 6y ago

> * As the pandemic eases are we in a situation needing to continue booster shots say on some reoccurring basis as a preventative measure?* Most likely. SARS-CoV-2 is now endemic in the human population & unlikely to die out. The general impression in the scientific community is that the current set of vaccines should be protective for at least a year or two, at which point variants will have emerged that evade the vaccines developed on the Wuhan strain. Booster shots developed on these new variants would be required for the foreseeable future. > Or something a bit more reactive where it is possible to get a shot after infected or having symptoms and whether mRNA works in this way as well on a reactive basis. In principle this is possible - some vaccines are capable of arresting an active infection, though that is highly specific to certain pathogens. This is not something current COVID vaccines can do.

Tagbert 6y ago

The mRNA vaccine process has been developed over the last 10 years or so. The actual spike protein was identified early, so the main work was to create the mRAN sequence for that protein. Not easy but the tools have gotten much better in recent years. This was the first large-scale use of this kind of vaccine so it is an amazing field test of the process. Normally that would be a slower, incremental process but the risk from Covid forced them to simplify and speed up the process.