The big difference between car drivers w/ "autopilot" and airline pilots with autopilot is that the airline pilots have massively increased training requirement

The big difference between car drivers w/ "autopilot" and airline pilots with autopilot is that the airline pilots have massively increased training requirements, regular re-certification, and physical fitness requirements. Even if plane vs automobile autopilots are equivalent in functionality, the difference in operator training is separated by multiple orders of magnitude. Not to mention the frequent presence of a second pilot in commercial airlines and a dedicated ATF crew on the ground to monitor their situation.