And in adult ferrets, generating totally a new (albeit undersized) tooth to replace a normal permanent tooth! That's a big deal since ferret teeth aren't parti

And in adult ferrets, generating totally a new (albeit undersized) tooth to replace a normal permanent tooth! That's a big deal since ferret teeth aren't particularly different from ours, while rodent teeth do all kinds of weird things like growing nonstop. It would have been awkward if we started human trials and found that instead of growing new teeth, the treatment just made our teeth get longer and longer. Like fingernails. Needing trimming. > Last, to confirm that USAG-1–neutralizing activity affects BMP signaling to generate a whole tooth in a nonrodent model, we systemically administered antibody #37 to postnatal ferrets that had both deciduous and permanent teeth. We observed supernumerary tooth formation in maxillary incisor like the third dentition, although a five times higher concentration, three administrations of antibody #37, and immunosuppression were required (Fig. 6, A to D). The supernumerary tooth was likely to have a similar shape to the usual permanent incisor, located to the lingual side of permanent teeth, whereas a shorter root seemed to be growing (Fig. 6, E to G). Therefore, this supernumerary incisor might be categorized as the third dentition (32). https://advances.sciencemag.org/content/7/7/eabf1798 https://advances.sciencemag.org/content/7/7/eabf1798