7 ms·
New biotech company from Bristol uses linoleic acid as pan coronavirus antiviral
- thro1 6y agoRelated: https://news.ycombinator.com/item?id=26842629 https://news.ycombinator.com/item?id=26842629 .
- thro1 6y ago.. Covid19 designer drugs.. . Druggable pocket in the SARS-CoV-2 spike protein: https://news.ycombinator.com/item?id=24567458 https://news.ycombinator.com/item?id=24567458, https://www.youtube.com/watch?v=EMaKFcpV5wg https://www.youtube.com/watch?v=EMaKFcpV5wg https://www.sciencemediacentre.org/expert-reaction-to-study- https://www.sciencemediacentre.org/expert-reaction-to-study-... The linoleic acid-binding pocket in SARS-COV-2 will make an attractive target for possible designer drugs.. . hrsACE2 as well inhibits binding: https://news.ycombinator.com/item?id=25008048 https://news.ycombinator.com/item?id=25008048 , https://www.youtube.com/watch?v=EMaKFcpV5wg https://www.youtube.com/watch?v=EMaKFcpV5wg APN001 is a hrsACE2 designed by Apeiron Biologics to imitate the human enzyme ACE2. hrsACE2 at tissue sites can effectively compete with the endogenous ACE2 and limits SARS-CoV-2 entrance into the host cells . ?
- thro1 6y agoFirst well-educated guess there may be something to look for - March 2020 (?): "Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?" https://europepmc.org/article/med/32229155 https://europepmc.org/article/med/32229155 (not yet about inhibiting binding)
- amluto 6y agoCoronaviruses are extremely easy to inactivate them. From memory, they are inactivated by soap, bleach, ethanol, sunlight (maybe), various surfactant-like disinfectants, and probably many other things. Admittedly, injecting fatty acids into one’s blood doesn’t seem quite as unwise as injecting bleach, but it still doesn’t sound like a great idea.
- thro1 6y ago> sunlight (maybe) Sunlight Neutralizes SARS-CoV-2 8x Faster Than Initially Assumed: https://news.ycombinator.com/item?id=26698047 https://news.ycombinator.com/item?id=26698047 . Other things to consider - for example lower cholesterol, omega ratios, beetroots? ;) : https://news.ycombinator.com/item?id=26843768 https://news.ycombinator.com/item?id=26843768 - "The metabolic fingerprint of Covid-19 severity" (it's a gem). edit: this research is more about inactivating by inhibiting the virus, before it enters the cell, using something that doesn't kill (virus is not alive anyway), another example is hrsACE2 which as well inhibits binding, discussed earlier: https://news.ycombinator.com/item?id=25008048 https://news.ycombinator.com/item?id=25008048 .
- amluto 6y agoSo obviously you should put a tanning lamp inside your body. Problem solved.
- klyrs 6y agoOh god, photon therapy just evolved. We're going to insert fiber optic cables into every major artery and give your blood a suntan. Absolutely nothing could go wrong.
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- thro1 6y agoBeetroots (may help with O2 saturation _when_ infected) are late and the UV lamp will be better inside of air filter outside of your body to not let the infection happen in the first place - light waves doesn't pass through the human body anyway - but other waves can. There it is: the resonance frequency of the virus ( https://www.livescience.com/7472-kill-viruses-shake-death.html https://www.livescience.com/7472-kill-viruses-shake-death.ht... , 2008) - icosahedral satellite tobacco necrosis virus of diameter of 18.4 nm resonates strongly around 60 GHz, according to Wikipedia the size of coronavirus is highly variable with average diameters of 80 to 120 nm, size of spikes 25 nm - so there may be no specific frequency of.. microwaves disintegrating the coronavirus by resonance, but it could be maybe one resonating with the spikes ? (UV light damages the DNA/RNA both of the virus and cell).
- AstralStorm 6y agoHow's the trial going? If it works, LA would be a nice cheap prophylactic.
- maxerickson 6y agoThey apparently haven't started a trial yet. https://globalbiodefense.com/2021/04/15/university-of-bristol-scientists-form-halo-therapeutics-to-develop-pan-corona-antivirals/ https://globalbiodefense.com/2021/04/15/university-of-bristo...
- atat7024 6y agoCannabis oil from vaporized loose leaf instead.
- maxerickson 6y agoPublication mentioned: https://science.sciencemag.org/content/370/6517/725 https://science.sciencemag.org/content/370/6517/725 They are currently fundraising for clinical trials.
- andrew_v4 6y agoIs there anything dangerous about linoleic acid? I.e. is there harm in trying it, even if it turns out it doesn't work? Just curious how a trial like this would go. If it's essentially benign, it seems like people could just use it, if it had some potential side effects then I guess it would be more complicated.
- maxerickson 6y agoIt's seed oil. They are talking about using it in inhalers, I don't know that I would be eager to try inhaling oil from some improvised setup. Adding some grapeseed oil or whatever to your diet wouldn't have any side effects.
- decebalus1 6y agoNot sure how this would be implemented. Lipid pneumonia is a thing. So is vaping-associated pulmonary injury (VAPI), the lung disease allegedly caused by vaping back in 2019 which was traced to Vitamin E acetate.
- HaloTx 5y agoIts not. Its the free fatty acid of the triglyceride. apples and organges.
- dilap 6y agoI wouldn't recommend it: https://www.bmj.com/content/346/bmj.e8707 https://www.bmj.com/content/346/bmj.e8707 (Also worth nothing Americans are already eating very high (and increasing) amounts of linoleic acid, and we have been hit pretty hard by the coronavirus.) (Should also note that linoleic acid is in tons of food; eating some is totally natural and healthy. "The dose makes the poison," as the old saying goes.)
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- henearkr 6y agoThat's safflower oil. But from another comment, lipid pneumonia is a thing, so I probably shouldn't start spraying safflower oil in my nasal cavity and pharynx...
- klyrs 6y agoI pan-fry sausages, which aerosolizes fats. I've been doing it for years and I don't think it's caused pneumonia... I'd reason that our lungs can tolerate a small dose of lipids per day, but a spritz up the nose doesn't sound great to me
- HaloTx 5y agoIts not actually. That is the triglyceride. LA is the free fatty acid of the plant oil.
- DoreenMichele 6y agoTo me, this sounds like "snake oil." Lipid pneumonia is a thing. Inhaling oils into your lungs is generally a bad idea.
- dogma1138 6y agoAt what dosage does that become a problem? Vaping liquids are glycol and glycerine based and while they are probably not particularly healthy compared to not vaping at all they don’t seem to cause lipid pneumonia that often.
- DoreenMichele 6y agoThe internet tells me glycerin is a component of oils but is, itself, miscible with water. The internet further tells me this means that, unlike oil, it mixes just fine with water. (People who know more chemistry than me: Feel free to correct me if I'm wrong.) The problem with oils is it blocks air flow into the lungs, kind of like how you oil a leather canteen so it doesn't leak. I've had a nebulizer. They are hard as all hell to keep adequately clean to be safe to use and some people have made themselves sick using an inadequately clean nebulizer. (This is similar to vaping.) I've known a couple of people who had lipid pneumonia, one of whom had a serious respiratory condition, was hanging out on email lists where we were discussing home remedies and they got the bright idea that breathing in some oil or other would be totes a good idea for some damn reason. Yeah, that wasn't such a hot idea after all.
- dogma1138 6y agoThe question here is does this lipid actually cause pneumonia and if so at what dosage, if it can be relatively easily metabolized or otherwise cleared from the tissue it might not be an issue in the first place. Yes nebulizers are hard to keep clean but that’s because they are essentially a petri dish and people who use them already have compromised lungs and or immune system. I don’t think people who vape keep their ecigs especially clean and at scale it doesn’t seem to cause too many issues. I can see a lot of reasons why this might not end up being effective but jumping to pneumonia is a bit of a stretch tbh. If this lipid isn’t toxic at a medically effective dosage you can probably have a hygienic delivery mechanism like an inhaler instead of a nebulizer.
- HaloTx 6y agoGuys Im a co-founder of the company Halo-Tx. Our work is based on a publication in Science Magazine. This is highest level science not "snake oil" stuff. This is not about inhaling vegetable oils: this is free fatty acids which are components of dietary oils, but also central elements of our metabolism and bodily function. Free fatty acids have decades of use as inactive ingredients in drug products, inhaled, nasal, and oral administration route. Dosing and safety parameters are not only known, they have been used by million of people in different drugs that are presently marketed. What we discovered is that the virus hijacks the body's natural free fatty acid pools to drive (turbocharge) its own replication, and a side effect is nasty inflammation because free fatty acids are the major inflammatory signaling precursors in the body (e.g. aspirin, and dexamethasone cools them off). P.S. dexamethasone is the only anti-inflammitory shown to have any effect in really sick COVID patients.
- msrenee 6y agoDo you have any studies in the works to discover efficacy? I'm also a little leery about an oil-based nasal spray. And not convinced that anything administered in this way would reach even the majority of the virus in your body. At best it seems like it might reduce your viral load. I'll look around your site more, but I'm seeing a lot of talk and not any hard data.
- HaloTx 5y agohttps://science.sciencemag.org/content/370/6517/725 https://science.sciencemag.org/content/370/6517/725
- msrenee 5y agoThanks for the link, but it doesn't address any of my concerns about whether it would be safe and effective when administered as a nasal spray. I was curious if you had any studies in the works to identify efficacy in animal models. I hate to bring out the tired old argument, but a flamethrower will kill cancer in a petri dish. Doesn't make it an effective therapy.
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