Having worked with all kinds of timezone differences, I'd say the toughest one is when it is just a couple hours, like pacific to eastern. With a small differe

Having worked with all kinds of timezone differences, I'd say the toughest one is when it is just a couple hours, like pacific to eastern. With a small difference it feels as if it is basically the same timezone so people schedule meetings with that assumption, but clearly it isn't. By the time I'm awake in California it's basically noon in EST. When most of my team was in India with a 12.5hr time difference it was actually easier because it was obvious to everyone that we're on opposite cycles so meetings were an exception and nobody expected real-time communication and acted accordingly.