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EPA, linolenic, linoleic acids inhibit ACE2 SARS-CoV-2 binding, cellular entry
- thro1 6y agoOriginal title: "Polyunsaturated ω-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry" (March 04, 2021). . A new drug target in the fight against COVID-19, University of Bristol (September 21, 2020): https://www.youtube.com/watch?v=EMaKFcpV5wg https://www.youtube.com/watch?v=EMaKFcpV5wg Discovery of a druggable pocket in the SARS-CoV-2 spike protein: https://news.ycombinator.com/item?id=24567458 https://news.ycombinator.com/item?id=24567458 Expert reaction to study on ‘druggable pocket’ in structure of SARS-CoV-2 virus spike: https://www.sciencemediacentre.org/expert-reaction-to-study-on-druggable-pocket-in-structure-of-sars-cov-2-virus-spike/ https://www.sciencemediacentre.org/expert-reaction-to-study-... The linoleic acid-binding pocket in SARS-COV-2 will make an attractive target for possible designer drugs.. . Oils Rich in Linoleic Acid (Safflower, Grapeseed 73%, Poppyseed, Sunflower, Hemp, Corn, Wheatgerm, Cottonseed, Soybean, Walnut, Sesame 45%) : https://www.news-medical.net/health/Oils-Rich-in-Linoleic-Acid.aspx https://www.news-medical.net/health/Oils-Rich-in-Linoleic-Ac... ?? ( BTW some comment from discussion about "Ultraprocessed Foods – A New Theory of Obesity": https://news.ycombinator.com/item?id=21073302 https://news.ycombinator.com/item?id=21073302 )
- thro1 6y agoThere was another discussion in November about hrsACE2 which as well inhibits binding: https://news.ycombinator.com/item?id=25008048 https://news.ycombinator.com/item?id=25008048 https://www.youtube.com/watch?v=EMaKFcpV5wg https://www.youtube.com/watch?v=EMaKFcpV5wg APN001 is a hrsACE2 designed by Apeiron Biologics to imitate the human enzyme ACE2. hrsACE2 at tissue sites can effectively compete with the endogenous ACE2 and limits SARS-CoV-2 entrance into the host cells