I don't necessarily see a problem with this on an n of 1 scale. Strongly held priors are not going to be updated by a single piece of research, and for the most

I don't necessarily see a problem with this on an n of 1 scale. Strongly held priors are not going to be updated by a single piece of research, and for the most part I don't feel they should be. Single studies in biology these days are pretty much never good enough to justify that. If over time many studies build up that's a different story. Perhaps there should be more review articles on HN rather than the focus on original research reports.