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Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age
- legerdemain 6y agoIt is rapidly becoming clear that inflammation drives many processes of disease and ageing. Many people are turning to anti-inflammatory diets rich in fruits like blueberries, fish with Omega Acids and turmeric. For example, there are many yoga practitioners in India who have extreme old age and great health that people worldwide can all benefit from listening to, like Baba Ramdev.
- cjmaria 6y agoI imagine you did not mean to imply that Baba Ramdev is of extreme old age, it seems he's only 55?
- alecco 6y agohttps://en.wikipedia.org/wiki/Ramdev#Claimed_cure_for_COVID-19 https://en.wikipedia.org/wiki/Ramdev#Claimed_cure_for_COVID-...
- waihtis 6y agoIf there's one thing that has become apparent during COVID, it's that there is great reason to be skeptical of "official government guidelines" of in situations like COVID (acutely emerging and constantly changing scenario.) They simply can't process information fast enough to make well informed statements. Now I don't have an opinion on ayurvedic medicine and it's legitimacy but something being "banned by the government" alone means nothing today.
- loopz 6y agoTraditional auyrveda and yoga is great. Cult leaders and wondercures aren't.
- waihtis 6y agoSo if something legitimate is being promoted by a "cult leader", it makes it illegitimate?
- loopz 6y agoNot necessarily. You just need to be aware of personal boundaries and how deep you are willing to go into it. At some point, a tradition need people to develop and keeping it alive vs benefits of participating in it. Awareness that no relationship last, is key.
- deleted 6y ago[deleted]
- TimSchumann 6y agoAnecdote, but this may explain why I feel so much healthier when I'm fasting regularly. Turns out, if you stop putting everything but water/salt in your body, there's not much left that causes inflammation.
- legerdemain 6y agoInflammation is a basic life process, not a reaction to the food you eat. Inflammation plays an active part in wound-healing. Teething in infants has an inflammatory component. Systemic inflammation is ubiquitous during and following parturition in mammals. There is inflammation everywhere, it's as generic a word as "oxidation" and "metabolism."
- tartoran 6y agoThat's like saying cell division is a basic life process and nothing can stop this process from going haywire, but what about cancer. It is widely believed that inflammation levels spike for certain foods and the overall effect on the body is not optimal to say the least.
- JMTQp8lwXL 6y agoThere's a middle ground: some is probably beneficial in certain cases, but you can have too much of a good thing-- then it's an issue.
- tartoran 6y agoYes, that is obvious. It is a natural process as much as apoptosis or cell suicide is.
- atat7024 6y agoEvery time you eat, the body enters a state of heightened inflammation. This is well documented. Please don't spread disinformation.
- jbritton 6y agoHow do you measure inflammation?
- legerdemain 6y agoSerum concentration of C-reactive protein and other molecular markers of ongoing inflammation processes.
- NotSammyHagar 6y agoYou made a lot of good comments on this article, do you have a background in nutrition?
- nabla9 6y agoHe has made horrible comments like > There is inflammation everywhere, it's as generic a word as "oxidation" and "metabolism." He is probably googling for answers and making it up as he goes.
- fsflover 6y agoNice try, NSA.
- NotSammyHagar 6y agoI'm just a regular programmer. I think if the NSA wanted to figure out who any of us are they can hack into hacker news and find out what IP address we have and look at our contact info and find me easily. Make sure you're using tor or something.
- atat7024 6y agoLook at it, feel its affects.
- asadkn 6y agoMost people talk food when inflammation is mentioned. But let's not forget, arguably, an even bigger contributor: stress - mental or physical, say via a chronic illness. Relevant: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476783/#s2title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476783/#s2titl...
- andreygrehov 6y agoCurious – are there legitimate ways to measure stress?
- koolba 6y agoYou could count the amount of hair loss or lack thereof. I bet hours of nightly REM sleep would be inversely correlated as well.
- raducu 6y agoI have terrible sleep, but my hours of REM sleep are fine. It's my deep sleep that's toast; also I get to the REM stage too quickly, I think it's supposed to be a sign of depression. So it's a bit more complicated.
- bbarnett 6y agoThere is nothing wrong with hair loss, it is perfectly natural, even when young and it doesn't mean you are getting old, not even a little bit, it even can look good, OK?
- koolba 6y agoI never said it’s not natural or that there’s anything wrong with it. It’s known to be associated with stress so barring other known factors, if you suddenly start losing your hair then stress could be a cause. In contrast to long term loss, short term loss from stress tends to be reversible if it’s caught early enough.
- lawwantsin17 6y agoThey really need a more nuanced word than inflamation, since there are no flames involved, just an immune system and chronic infection.
- derefr 6y agoAnyone know how long mice live with all the genes for inflammatory responses knocked out?
- pmiller2 6y agoSuch an organism probably wouldn’t be compatible with life. Inflammation is necessary for healing wounds and immune response, among other things.
- sparrc 6y agoIt's always strange to me how certain studies seem to gain so many upvotes on hackernews....a few thoughts: 1. This is a single study published in 2015, what does the wider literature say? Any dieticians or clinicians recommending anything from this? 2. The journal is EBioMedicine, which is not nothing but not exactly pre-eminent either. 3. This seems like just a common sense conclusion: "In Cox proportional hazard models, inflammation predicted all-cause mortality". So...people who die have inflammation? Wouldn't that be expected that people who are dieing are likely experiencing significant inflammation of at least one organ of their body? 4. In short, the conclusion of this paper seems like essentially "people who are dying are likely to die". Am I missing something here?
- deleted 6y ago[deleted]
- johnisgood 6y agoI suppose emphasis is on this: "telomere length was not a predictor of successful ageing".
- sparrc 6y agoyet everyone in the comments is sounding off as if this scientifically proves their random anecdotes about fasting
- andy_ppp 6y agoWhat’s wrong with fasting, isn’t it likely to increase life expectancy. I certainly feel better from this attempt at Ramadan (not religious just interested to try it as flat mate is Syrian). What evidence do you have that fasting -> less inflammation -> better ageing is wrong?
- loopz 6y agoFasting is good when following recommendations. But people in West are very ignorant about the practice still. It's natural to be sceptical about foreign practices, until they become medicine.
- mrwaffle 6y agohi, i'm a just stupid waffle. can someone give me the TLDR of this [nearly] impossible to understand piece of writing?
- pazimzadeh 6y ago> We conclude that inflammation is an important malleable driver of ageing up to extreme old age in humans
- mattowen_uk 6y agoFrom what I understand, is that if your body is quite good at fighting infection (and thus creates inflammation) you'll live longer. Seems a bit obvious to me, but what do I know? I'm not an academic scientist...
- jobigoud 6y agoIt's the other way around. Their finding is that lower levels of inflammation correlates with survival, capability and cognition in centenarians.
- mattowen_uk 6y agoAhhh. Thanks!
- mrwaffle 6y agothis is the ideal reply, original waffle poster was hoping for, thank you!
- kgin 6y agoEpigenetic clocks measuring methylation sites across DNA are currently the most accurate way to measure aging https://en.wikipedia.org/wiki/Epigenetic_clock https://en.wikipedia.org/wiki/Epigenetic_clock What's more, it seems that it is possible to reset the epigenetic of cells to their youthful state and reverse actual the biological age of those cells. They don't just "measure younger", they function as they did when they were younger. https://www.nature.com/articles/s41586-020-2975-4 https://www.nature.com/articles/s41586-020-2975-4
- perl4ever 6y ago>currently the most accurate way to measure aging I don't understand what people mean by statements like this. Per the Wiki page, they found something that on average is highly correlated to chronological age. But in individual cases, it may be off a little or a lot. What tells you this is meaningful information and not random noise? What is the reference point for the "real" age that is not chronological age?
- fao_ 6y ago> But in individual cases, it may be off a little or a lot. What tells you this is meaningful information and not random noise? Because it was more accurate than other data sources we've tried
- perl4ever 6y agoIt appears to me to be "more accurate" because they have defined the discrepancies as more accurate. Why not just define them as inaccuracy?
- chub500 6y agoI just watched an interesting Veritasium on this aspect of aging: https://m.youtube.com/watch?v=QRt7LjqJ45k https://m.youtube.com/watch?v=QRt7LjqJ45k
- jaygernaught 6y agointeresting, what are your thoughts on modifying our epigenetics via crisper to pulse Yamanaka factors? also what ever happened to that CEO who gave her immune system a boost with stem cells?
- Robotbeat 6y agoWhat is inflammation, exactly?
- mattowen_uk 6y agoRedness round a sore or cut? Inflammation. Swollen gums around a dying tooth? Inflammation. Sore stomach due to food intolerance? Inflammation.
- Robotbeat 6y agoBut what is inflammation?
- frombody 6y agoIt's an immune system response. It's your body trying to fix itself. If you get injured, the inflammation around the wound is signaling your body to bring white blood cells to that location. Unless you have some sort of imbalance in your body, like a genetic issue, it's usually better to target controlling the source of the inflammation rather than the inflammation itself. Inflammation can be more mental than physical in many cases, as your body is going to react to your environment and the way you perceive it and raise and lower your cortisol levels accordingly. This likely doesn't answer your question fully, but just some items to consider.
- deleted 6y ago[deleted]
- ibigb 6y agoI found this interview very germane to the subject of extra inflammation from the diet and the newly discovered cellular mechanisms for turning it off. Some of the latest research from a few years ago. https://www.youtube.com/watch?v=SXm28_2ctpU https://www.youtube.com/watch?v=SXm28_2ctpU "23 Years in the Zone: Journalist and Author Gary Taubes Interviews Dr. Barry Sears"