4 ms·
Can you explain why for those of us unfamiliar?
by galangalalgol 6y ago
Can you explain why for those of us unfamiliar?
- realce 6y agoWell it's not actually a placebo to start with.
- AstralStorm 6y agoThere is no way to placebo control a psychedelic really, as that effect is easily discerned, even in a closed label trial. Therefore, a comparison protocol is used instead, which is anyway superior to pure placebo control. A different psychedelic, which is not expected to have an antidepressant effect, or a low, psychoactive but not antidepressant dose. Or known non-psychedelic antidepressants which have been placebo tested.
- ghgdynb1 6y agoI think the concern is that you could still be getting pharmacodynamic effects at 1mg, so the control wouldn’t really be a control. It’s entirely feasible that you could get good results and limited side effects at dose x, and poor results overwhelmed by side effects at dose 25x.