Studies are being designed to reduce the possibility that a patient just didn't respond well to one medication but instead shows a general lack of improvement f

Studies are being designed to reduce the possibility that a patient just didn't respond well to one medication but instead shows a general lack of improvement from antidepressants. The goal is to know that the patient improved from psilocybin, specifically. One other problem with this stacked definition of treatment resistance is that doctors are going to be coerced to always try multiple antidepressants and guinea pig the hell out of patients. Doctors are going to refuse initial psilocybin treatment and only use it as a last resort because the studies are going to show that treatment resistance is necessary. Even worse will be if doctors are coerced by regulators and medical institutes to strictly follow their protocol. And this only includes doctors who agree to add psilocybin to their treatment programs. A lot of doctors will resist using it, claiming "unearned wisdom is dangerous wisdom" and so forth. The "unearned wisdom" claim is based on the indoctrinated belief that a patient must undergo many hours of therapy and slowly peel layers of experience in order to truly understand, whereas psilocybin offers a shortcut. For these reasons and others, I believe that the vast majority of depressed people who haven't healed from traditional methods ought not pursue clinical studies as a viable pathway to psilocybin-assisted therapy.