The 1 mg dose wasn't daily, it was 3 weeks apart. From the study: Patients were assigned in a 1:1 ratio to receive two separate doses of 25 mg of psilocybin 3

The 1 mg dose wasn't daily, it was 3 weeks apart. From the study: Patients were assigned in a 1:1 ratio to receive two separate doses of 25 mg of psilocybin 3 weeks apart plus 6 weeks of daily placebo (psilocybin group) or two separate doses of 1 mg of psilocybin 3 weeks apart plus 6 weeks of daily oral escitalopram (escitalopram group); all the patients received psychological support. https://www.nejm.org/doi/full/10.1056/NEJMoa2032994 https://www.nejm.org/doi/full/10.1056/NEJMoa2032994