3 ms·
It seems the design of this study is questionable. Since they couldn't blind the psylocybin group from the effect, they gave 1mg daily to the SSRI group. Basi
by satellite2 6y ago
It seems the design of this study is questionable.
Since they couldn't blind the psylocybin group from the effect, they gave 1mg daily to the SSRI group.
Basically it's a study that compares psylocybin with SSRI + psylocybin micro dosing.
They claim that the micro dose don't have an effect, but there is not a large body of evidence to support that claim.
- 8192kjshad09- 6y agoWouldn't the study design under exaggerate the effect of psilocybin, if anything?
- jxding 6y agoTo be a little pedantic, I'm not sure "under exaggerate" is a valid phrase. What you're looking for may be "under-report"?
- qntty 6y agoThe 1 mg dose wasn't daily, it was 3 weeks apart. From the study: Patients were assigned in a 1:1 ratio to receive two separate doses of 25 mg of psilocybin 3 weeks apart plus 6 weeks of daily placebo (psilocybin group) or two separate doses of 1 mg of psilocybin 3 weeks apart plus 6 weeks of daily oral escitalopram (escitalopram group); all the patients received psychological support. https://www.nejm.org/doi/full/10.1056/NEJMoa2032994 https://www.nejm.org/doi/full/10.1056/NEJMoa2032994