Missing a lot of signals from the in vivo context - for example taking a naive approach to organoids typically means you’re going to be missing vascularization,

Missing a lot of signals from the in vivo context - for example taking a naive approach to organoids typically means you’re going to be missing vascularization, which is essential for the architecture of the brain in vivo. Also typically organoids present as very immature brains, whereas Alzheimer's patients sort of have "maximally mature" brains.