3 ms·
There’s a remarkable amount of hyperbole in this article (but not the original publication). In plain language, this is a project to generate, characterize, and
by benrapscallion 6y ago
There’s a remarkable amount of hyperbole in this article (but not the original publication). In plain language, this is a project to generate, characterize, and openly share the data for iPSC models (and presumably neurons from them) bearing 100 APOE disease-associated mutations.
It must be remembered that one reason many AD drugs have failed is because models don’t capture the disease accurately and that may well turn out to be the case here.
- kick_in_the_doo 6y agoDo AD drugs attempt to reduce the concentration of APOE in the brain? If so, is it known if these drugs either failed to reduce the concentration of APOE, or succeeded in reducing concentration but still didn't work?
- benrapscallion 6y ago“Reduce APOE” is an oversimplified view. The mechanisms by which the AD-associated E4 genotype (arg112, arg158) results in disease are still poorly understood. The main therapeutic hypothesis for AD is to reduce the levels of pathogenic plaques and aggregates using antibodies.
- kick_in_the_doo 6y agoInteresting. And these studies have shown that medicine which reduces these plaques doesn't actually help with AD symptoms?
- dang 6y agoI've pinched the title from https://www.ninds.nih.gov/News-Events/News-and-Press-Releases/Press-Releases/NIH-scientists-try-new-twist-using-personalized-stem-cells https://www.ninds.nih.gov/News-Events/News-and-Press-Release..., which the OP points to, since it seems less hyperbolic and more precise. Not sure if the article itself should be changed also...