3 ms·

That's interesting to know. When I got my Pfizer jab, the lady said "oops, I did it wrong" and blood came out. She didn't jab me again though and I just assumed

That's interesting to know. When I got my Pfizer jab, the lady said "oops, I did it wrong" and blood came out. She didn't jab me again though and I just assumed it was good to go. Should she have done it again at a different site? I was told elsewhere that it doesn't make the vaccine any less effective, but I'm curious what others on here think now...

UncleOxidant 6y ago
As I understand it the concern isn't effectiveness so much as potential for side effects. An intramuscular injection is meant to stay pretty much in a small area of muscle tissue. If it goes into the vein the vaccine then travels into tissues all over the body.
- robbiep 6y ago
  That’s not really true, we give lots of drugs IM because the muscle is highly vascular so it generally shoots out all over the body really quickly. Ie want to take down a patient with Ice (crystal meth) induced psychosis? IM. Also, it’s hard to miss most of the time. If you want something to sit around for a long time, you go for less vascular areas. (Ie insulin for diabetics, subcut abdominal fat) IM is preferred because of the vascularity which helps in the immune response (ie quick immune response, antigen distributed around the body) as well as any immune reaction confined to the muscle rather than, say the skin. (0) is a quick and dirty on mechanisms of administration. To your earlier point about ‘into’ a vein, I’d never heard of Dr Campbell before you mentioned him, he seems to have great credentials, but I can’t easily explain why an accidental IV administration of an IM vaccine would cause CVST, my gut is that it’s a bit of a hand wave but who knows. (0) https://www.forbes.com/sites/quora/2017/11/07/why-arent-vaccines-given-intravenously/?sh=4cbb5da6798c https://www.forbes.com/sites/quora/2017/11/07/why-arent-vacc...
  - amluto 6y ago
    IV injection of adenovirus gene therapy vectors is well known to cause thrombocytopenia.
    - deleted 6y ago
      [deleted]
    - robbiep 6y ago
      Right, thanks, I wasn’t aware. Time periods seem off (5-14hrs) in mouse models compared to what’s being seen here though, which seems more like an immune reaction rather than a response to the antigen/delivery system
- catblast01 6y ago
  That makes no sense of course. You’re innoculating the whole body, especially bone marrow and lymph nodes, not a small area of muscle.

UncleOxidant 6y ago

As I understand it the concern isn't effectiveness so much as potential for side effects. An intramuscular injection is meant to stay pretty much in a small area of muscle tissue. If it goes into the vein the vaccine then travels into tissues all over the body.

robbiep 6y ago
That’s not really true, we give lots of drugs IM because the muscle is highly vascular so it generally shoots out all over the body really quickly. Ie want to take down a patient with Ice (crystal meth) induced psychosis? IM. Also, it’s hard to miss most of the time. If you want something to sit around for a long time, you go for less vascular areas. (Ie insulin for diabetics, subcut abdominal fat) IM is preferred because of the vascularity which helps in the immune response (ie quick immune response, antigen distributed around the body) as well as any immune reaction confined to the muscle rather than, say the skin. (0) is a quick and dirty on mechanisms of administration. To your earlier point about ‘into’ a vein, I’d never heard of Dr Campbell before you mentioned him, he seems to have great credentials, but I can’t easily explain why an accidental IV administration of an IM vaccine would cause CVST, my gut is that it’s a bit of a hand wave but who knows. (0) https://www.forbes.com/sites/quora/2017/11/07/why-arent-vaccines-given-intravenously/?sh=4cbb5da6798c https://www.forbes.com/sites/quora/2017/11/07/why-arent-vacc...
- amluto 6y ago
  IV injection of adenovirus gene therapy vectors is well known to cause thrombocytopenia.
  - deleted 6y ago
    [deleted]
  - robbiep 6y ago
    Right, thanks, I wasn’t aware. Time periods seem off (5-14hrs) in mouse models compared to what’s being seen here though, which seems more like an immune reaction rather than a response to the antigen/delivery system
catblast01 6y ago
That makes no sense of course. You’re innoculating the whole body, especially bone marrow and lymph nodes, not a small area of muscle.