If you use multiplexers you can connect a lot more devices (upto 64*254 = 16256 I think) on a single bus. https://learn.adafruit.com/adafruit-tca9548a-1-to-8-i

If you use multiplexers you can connect a lot more devices (upto 64*254 = 16256 I think) on a single bus. https://learn.adafruit.com/adafruit-tca9548a-1-to-8-i2c-multiplexer-breakout/overview https://learn.adafruit.com/adafruit-tca9548a-1-to-8-i2c-mult... You could of course design your own multiplexer with more bytes of multiplexer address space and extend the concept indefinitely. I wouldn't recommend it, but it's possible.