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Yes, they are meaningfully different. For one, Pfizer and Moderna are mRNA vaccines, while J&J and AZ are not.

• Moto7451 5y ago
  That’s not the difference the parent is asking about. He’s asking if the adenovirus based vaccines available are meaningfully different. Reaching beyond the parent’s words, both AstraZeneca and J&J have now had issues with blood clots. If it’s a similar formulation then perhaps you’ve found something and Adenovirus vaccines with a different formulation are unaffected. If they’re very different then perhaps other variations of Adenovirus vaccines need more attention.
  • viklove 5y ago
    The mechanism of delivery isn't a meaningful difference? Okay, if you just want to ignore half of the equation be my guest.
    • ivalm 5y ago
      They are comparing jj and astro zeneca, both use adenovirus delivery. Albeit very different variants.
    • GavinMcG 5y ago
      The parent comment wondered > whether Johnson & Johnson and AstraZeneca are meaningfully different Grammatically, that asks about the difference between J&J & AZ. Your response instead compared them collectively to the mRNA vaccines, rather than comparing them to each other. Thus the response saying "[t]hat’s not the difference the parent is asking about."