5 ms·
Well this seems stupid. The thing I'm trying to understand is whether Johnson & Johnson and AstraZeneca are meaningfully different. All the media just assumes
by Ericson2314 6y ago
Well this seems stupid.
The thing I'm trying to understand is whether Johnson & Johnson and AstraZeneca are meaningfully different. All the media just assumes they are (until proven equivalent), but is the genetic code publicly known so we can compare? The Pfizer and Moderna ones are extremely similar. Now, I imagine the adenovirus ones have an order of magnitude more genetic material, but is the code publicly know to compare?
As far as I can tell, they both should have been approved ages ago, if only to depress prices and get more redundancy.
- viklove 6y agoYes, they are meaningfully different. For one, Pfizer and Moderna are mRNA vaccines, while J&J and AZ are not.
- Moto7451 6y agoThat’s not the difference the parent is asking about. He’s asking if the adenovirus based vaccines available are meaningfully different. Reaching beyond the parent’s words, both AstraZeneca and J&J have now had issues with blood clots. If it’s a similar formulation then perhaps you’ve found something and Adenovirus vaccines with a different formulation are unaffected. If they’re very different then perhaps other variations of Adenovirus vaccines need more attention.
- viklove 6y agoThe mechanism of delivery isn't a meaningful difference? Okay, if you just want to ignore half of the equation be my guest.
- ivalm 6y agoThey are comparing jj and astro zeneca, both use adenovirus delivery. Albeit very different variants.
- GavinMcG 6y agoThe parent comment wondered > whether Johnson & Johnson and AstraZeneca are meaningfully different Grammatically, that asks about the difference between J&J & AZ. Your response instead compared them collectively to the mRNA vaccines, rather than comparing them to each other. Thus the response saying "[t]hat’s not the difference the parent is asking about."
- gher-shyu3i 6y agoDoes the fact that they're made in the same lab mean anything when it comes to these side effects? Are the fillers/stabilizing materials the same?
- tobessebot 6y agoJ&J uses a very rare human adenovirus, AZ uses a more common chimpanzee adenovirus. J&J also has the so-called 2PP modification on the Spike protein compared with the AZ vaccine. Good writeup here: https://berthub.eu/articles/posts/genetic-code-of-covid-19-vaccines/ https://berthub.eu/articles/posts/genetic-code-of-covid-19-v...
- Ericson2314 6y agoThanks! I greatly enjoyed https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/ https://berthub.eu/articles/posts/reverse-engineering-source... before, and somehow missed the same author had one on the adenovirus vaccines.
- whazor 6y agoOne difference is that J&J has been tested for only one shot and AZ is tested for two shots. Also the amount of vaccin you get shot in your arm could be different. The clotting incidents between the two are certainly different, AZ has much more at the moment.