I think LuaTeX may have been sort-of capable for a while (with enough effort/workarounds by the user), but in 2019 or earlier, there was some work (initially by

I think LuaTeX may have been sort-of capable for a while (with enough effort/workarounds by the user), but in 2019 or earlier, there was some work (initially by Khaled Hosny, who was also one of the major XeTeX maintainers a while ago) to have LuaTeX use HarfBuzz. (See http://tug.org/TUGboat/tb40-1/tb124hosny-harfbuzz.pdf http://tug.org/TUGboat/tb40-1/tb124hosny-harfbuzz.pdf) So (after some more work by the LuaTeX team) there's a LuaTeX variant called LuaHbTeX, which is the program invoked (since TeX Live 2020) when you write `lualatex`. The end result is that, to the best of my knowledge, LuaTeX can handle many of these things just as well as XeTeX. (See http://tug.org/TUGboat/tb41-1/tb127fischer-bangla.pdf http://tug.org/TUGboat/tb41-1/tb127fischer-bangla.pdf for an article from 2020, focusing on the case of the Bangla script, which is not right-to-left, but like all Indic/Brahmic scripts has some other issues related to complex text layout.)