5 ms·
Suboxone is the trademark name of a eponymous mix of the inhibitor Naloxone added to Buprenorphine. Many formulations contain small enough amounts of Naloxone
by Cullinet 5y ago
Suboxone is the trademark name of a eponymous mix of the inhibitor Naloxone added to Buprenorphine.
Many formulations contain small enough amounts of Naloxone to permit a addict to take opiates without any significant adverse effects within a few hours.
The reason why people use the name synonymously is because Buprenorphine is a Mu Kappa Delta antagonist with sufficiently higher affinity to those receptors making it very much harder for other opiods to bind preferentially. Slow release formulation and slow linear bioavailability decline profiles suffice to do the rest of the job of making say heroin ineffective if the patient takes anything else.
I'm saying this so no one is under any impression that Suboxone is a safe drug for anyone to take (accidentally or otherwise) and off the top of my head a commonly used 8mg dose is roughly 100mg Morphine equivalent.
https://www.gloshospitals.nhs.uk/gps/treatment-guidelines/opioid-equivalence-chart/ https://www.gloshospitals.nhs.uk/gps/treatment-guidelines/op...
- heavyset_go 5y agoNaloxone isn't orally active, so it isn't actually inhibiting anything for people who aren't abusing it. The opioid blocking effect comes from buprenorphine itself, as it is a partial agonist with a high binding affinity. It binds preferentially to the mu-opioid receptor compared to many opioids, and as a partial agonist, it has a weaker effect than some other opioids.