5 ms·

He's also, iirc, working on getting a healthier, synthetic, reversible alternative to alcohol approved in legislation. But I'm not holding my breath

LeoPanthera 6y ago
If they don't call it synthehol I will be very disappointed.
emsy 6y ago
It already exists: GHB. The problem is the drug’s reputation and the problem with dosage, which could be alleviated when legalized. It’s also addictive but then again, so is alcohol but alcohol wrecks your health.
- Tenoke 6y ago
  I agree but sadly I don't see something so dosage-dependent ever becoming mainstream. Another GABAergic in a similar vein might have a better chance.
- n4r9 6y ago
  Is GHB reversible?
  - emsy 6y ago
    No I didn't get that quite right. Still GHB is a major improvement upon alcohol and I think the dosage problem is mainly an issue of illegality. It's fairly dosable and redosable when you know what exactly you're ingesting. Also GHB doesn't disinhibit aggression as much as alcohol does.
- mam2 6y ago
  Ghb leads to memory problems, its addictive and indeed, mistakes in dosages can send you right to a heart attack.. Source : addiction happened to people i met and the HR happened in a friends party.
  - serf 6y ago
    > Ghb leads to memory problems, its addictive and indeed, mistakes in dosages can send you right to a heart attack.. sounds like caffeine (from those criteria) [0]: https://en.wikipedia.org/wiki/Effect_of_caffeine_on_memory https://en.wikipedia.org/wiki/Effect_of_caffeine_on_memory [1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777290/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777290/ [2]: https://www.webmd.com/heart-disease/news/20060815/coffee-may-trigger-heart-attack https://www.webmd.com/heart-disease/news/20060815/coffee-may...
    - maxerickson 6y ago
      Love the "(from those criteria)". It's pretty easy to drink 3 cups of coffee and not come anywhere near overdosing on caffeine. And then after that you can drink 3 more. And then after that you are probably sick of coffee, but go ahead and drink 3 more if you really want. How's the recreational dosing of GHB go?
      - ipsum2 6y ago
        To be fair, some people have died from caffeine overdose when ingesting pure caffeine, which lead many internet retailers to not carry them any more. Example: https://www.inquisitr.com/1909754/caffeine-powder-death-teaspoon-serving-equal-to-25-cups-of-coffee-amazon-still-sells-anhydrous-pills-amid-lawsuit/ https://www.inquisitr.com/1909754/caffeine-powder-death-teas...
        maxerickson 6y ago
        What the hell does fair mean then? I've never taken GHB and don't plan to, but it looks like a recreational dose is ~1/2 of a dangerous dose, both of which would be (at least somewhat) difficult to obtain. With caffeine, the typical recreational dose is a beverage that is easily obtained and isn't dangerous. That you could buy caffeine powder doesn't make that a typical way to consume it. Apparently 500 mg of caffeine is considered potentially dangerous. That would be 5 or 6 cups of coffee (I'm in the habit of drinking that much coffee and have a pretty low resting heart rate during the consumption, so I dunno).
Tenoke 6y ago
I talked to him about it when I met him 10 years ago and was much more optimistic then. As far as I know this isn't any closer to being on the market now than it was back then.
antihero 6y ago
I think the issue is that drinking is about far far more than simply getting drunk.

LeoPanthera 6y ago

If they don't call it synthehol I will be very disappointed.

emsy 6y ago

It already exists: GHB. The problem is the drug’s reputation and the problem with dosage, which could be alleviated when legalized. It’s also addictive but then again, so is alcohol but alcohol wrecks your health.

Tenoke 6y ago
I agree but sadly I don't see something so dosage-dependent ever becoming mainstream. Another GABAergic in a similar vein might have a better chance.
n4r9 6y ago
Is GHB reversible?
- emsy 6y ago
  No I didn't get that quite right. Still GHB is a major improvement upon alcohol and I think the dosage problem is mainly an issue of illegality. It's fairly dosable and redosable when you know what exactly you're ingesting. Also GHB doesn't disinhibit aggression as much as alcohol does.
mam2 6y ago
Ghb leads to memory problems, its addictive and indeed, mistakes in dosages can send you right to a heart attack.. Source : addiction happened to people i met and the HR happened in a friends party.
- serf 6y ago
  > Ghb leads to memory problems, its addictive and indeed, mistakes in dosages can send you right to a heart attack.. sounds like caffeine (from those criteria) [0]: https://en.wikipedia.org/wiki/Effect_of_caffeine_on_memory https://en.wikipedia.org/wiki/Effect_of_caffeine_on_memory [1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777290/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777290/ [2]: https://www.webmd.com/heart-disease/news/20060815/coffee-may-trigger-heart-attack https://www.webmd.com/heart-disease/news/20060815/coffee-may...
  - maxerickson 6y ago
    Love the "(from those criteria)". It's pretty easy to drink 3 cups of coffee and not come anywhere near overdosing on caffeine. And then after that you can drink 3 more. And then after that you are probably sick of coffee, but go ahead and drink 3 more if you really want. How's the recreational dosing of GHB go?
    - ipsum2 6y ago
      To be fair, some people have died from caffeine overdose when ingesting pure caffeine, which lead many internet retailers to not carry them any more. Example: https://www.inquisitr.com/1909754/caffeine-powder-death-teaspoon-serving-equal-to-25-cups-of-coffee-amazon-still-sells-anhydrous-pills-amid-lawsuit/ https://www.inquisitr.com/1909754/caffeine-powder-death-teas...
      - maxerickson 6y ago
        What the hell does fair mean then? I've never taken GHB and don't plan to, but it looks like a recreational dose is ~1/2 of a dangerous dose, both of which would be (at least somewhat) difficult to obtain. With caffeine, the typical recreational dose is a beverage that is easily obtained and isn't dangerous. That you could buy caffeine powder doesn't make that a typical way to consume it. Apparently 500 mg of caffeine is considered potentially dangerous. That would be 5 or 6 cups of coffee (I'm in the habit of drinking that much coffee and have a pretty low resting heart rate during the consumption, so I dunno).

Tenoke 6y ago

I talked to him about it when I met him 10 years ago and was much more optimistic then. As far as I know this isn't any closer to being on the market now than it was back then.

antihero 6y ago

I think the issue is that drinking is about far far more than simply getting drunk.