The first example would be easier than the second, but yes, you could technically do both. The second one has more pixel-based textures (like the drawings), and

The first example would be easier than the second, but yes, you could technically do both. The second one has more pixel-based textures (like the drawings), and you could certainly use those as layer fills, though I wouldn't advise trying to draw them there. I wouldn't say that either Sketch or Figma handle pixel artwork particularly well, because they're both optimized for vectors, but you can import and manipulate that kind of artwork (move, resize, crop, change color properties, etc.) fairly well. It might be worth checking out Affinity Photo and Affinity Designer as lighter, cheaper alternatives that handle pixels better. But PS is still the best tool for this, sure.